Downstream Scientist
| Company: | SRG |
|---|---|
| Salary: | £26,939 - £36,000 |
| Hours: | Full-time |
| Location: | Darlington, DL1 1GL |
| Job type: | Permanent |
| Posting date: | 13 Aug 2026 |
| Closing date: | 12 Sept 2026 |
Summary
Downstream Process Development Scientist
Permanent | Darlington | £26,939- £36,000 per annum + attractive benefits
About the Role
CPI is seeking a hands-on
Downstream Process Development Scientist to join their bioprocessing team in Darlington on a permanent basis.
This is a practical, lab-based role focused on the
design, development, and optimisation of downstream purification processes for advanced biologics. You will play a key role in delivering DSP activities across a range of modalities, including viral vectors and nucleic acid-based products, in a fast-moving and highly experimental environment.
Reporting into the DSP leadership team, will be responsible for running experiments, solving problems, and adapting processes, as projects evolve. This role suits someone who enjoys flexibility, iteration, and scientific creativity rather than rigid, highly constrained environments.
The role is based on-site in Darlington, working as part of an established DSP team of approximately 11 scientists.
What You'll Be Responsible For
Downstream Process Development
- Design, develop, and optimise downstream purification processes for biopharmaceutical products
- Carry out hands-on laboratory experimentation and pilot-scale DSP runs
- Apply chromatography and filtration techniques to improve yield, purity, and robustness
Chromatography & Filtration
- Operate and develop chromatography methods using
- Design and optimise and run chromatographic purification strategies
- Apply
ÄKTA systems
tangential flow filtration (TFF) and related DSP technologies
Analytical & Data Interpretation
- Analyse and interpret experimental data using techniques such as:
- ELISA
- HPLC / UPLC
- SDS-PAGE
- Maintain high-quality experimental records using ELN and document management systems
- Present experimental conclusions clearly for internal and external stakeholders
Collaboration & Laboratory Operations
- Work closely with upstream, analytical, and project teams to deliver customer programmes
- Contribute to the efficient operation of the DSP laboratory, including equipment care and maintenance
- Support scale-up, knowledge transfer, and process troubleshooting activities
About You
You are a
practical downstream processing scientist who enjoys being in the lab and is comfortable working in an evolving, sometimes ambiguous research and development environment.
You bring curiosity, adaptability, and a willingness to try different approaches - and you're not phased by processes that aren't fully defined from day one.
You'll bring:
- Demonstratable experience of planning and delivering complex laboratory technical work, data analysis and reporting
- Theoretical and practical knowledge in Biochemistry, Biologics Purification, Biochemical Engineering and relevant analytical techniques.
- Experience designing and optimising chromatography-based purification processes
- Familiarity with
- Flexibility to adjust working hours around experimental needs
TFF, ELISA, and HPLC/UPLC techniques
Desirable (but not essential):
- Experience using
ÄKTA chromatography systems
- Experience working with
- Background beyond monoclonal antibodies (mAbs)
- Experience in early-stage, development-focused or non-rigid GMP environments
AAV, viral vectors, or DNA/RNA-based products
Applicants from academia are welcome.
Why Join CPI?
- A genuinely hands-on laboratory role with real scientific ownership
- Exposure to emerging modalities and advanced bioprocessing technologies
- A collaborative team that values experimentation and problem-solving
Location & Working Pattern
- Based on-site in
- Flexible working hours aligned to experimental requirements
Darlington
Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy.
Related jobs
Research Scientist - Colloids
£26,939 to £41,000 per year
SRG
Sedgefield, County Durham
PermanentFull timeJunior Warehouse Coordinator
£25,947.47 to £29,556 per year
Centre for Process Innovation
Newton Aycliffe, United Kingdom
On-sitePermanentFull time